The AIM system is seamlessly compatible with all aspects of high-throughput screening assays and equipment. ARLD’s patent pending engineered surface structures, integrated into these convenient-to-use functional AIM lids, insure both excellent reproducibility of droplet volumes and reliable droplet adhesion. All types of hydrogels, including alginate and collagen, adhere well to the AIM lid surface. AIM Lids currently fit all standard 96 well microplates. Lids for 384 and 1536 well microplates will be available soon.
The Anchored Immersion Microplate (AIM) Lid enables the conversion of standard 2D microplates into a system for 3D cell culture and assays. These functional lids securely anchor precise microliter volumes of hydrogels that can be repeatedly immersed into media in standard microplates for 3D cell culture and/or compound screening, speeding and simplifying media changes. An entire AIM Lid can be loaded with cell-containing hydrogel droplets in seconds.
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To address the rapidly evolving needs of cell researchers working in drug discovery, ARLD has developed the The Nano-Droplet Array Plate (nDAP) which enables the culturing and analysis of high-density arrays of cells immobilized within a 3D hydrogel environment.
The ARLD nDAP system consists of the nDAPs and a low-cost dispensing robot. Liquids of any surface tension can be rapidly dispensed onto the nDAP in precise nano-liter or pico-liter volumes, where they are anchored during assay steps. Because the diameter of the nDAP post determines the volume of solution dispensed, low cost robotics can be used to achieve very high dispense precision. The nDAP surface flips the standard dispensing process, making it far more precise, yet highly tolerant of mechanical misalignment.